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Prognosis of patients with recurrence after curative resection of advanced gastric cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 107-110, 2011.
Article in Chinese | WPRIM | ID: wpr-237162
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical features and prognosis of recurrent gastric cancer.</p><p><b>METHODS</b>Clinical data of 163 patients with recurrent gastric cancer from Jan. 2001 to Jan. 2005 were reviewed. Patients were compared between those with and without symptoms.</p><p><b>RESULTS</b>Seventy-two patients(44.2%) were symptomatic, while 91(55.8%) were asymptomatic. There were significant differences in lymph node metastasis between the two groups(P<0.05). The median overall survival was significantly longer in asymptomatic patients (19.8 vs. 15.7 months, P<0.05). Post-recurrence survival was also longer in the asymptomatic group (9.5 vs. 4.8 months, P<0.01). The median recurrence-free interval in asymptomatic patients was 10.0 months, which was significantly longer than that in the symptomatic patients (9.2 months, P<0.05). On univariate survival analysis,post-gastrectomy chemotherapy (P<0.05), symptoms of recurrence(P<0.01), TNM staging(P<0.01), recurrence-free interval (P<0.01), and reoperation(P<0.01) were associated with the prognosis. On multivariable analysis, TNM staging(P<0.01), symptoms of recurrence(P<0.01), recurrence-free interval (P<0.05), and reoperation(P<0.05) were independent risk factors.</p><p><b>CONCLUSIONS</b>Patients with recurrent gastric cancer have poor prognosis. Close monitoring and active follow-up of patients with gastric cancer should be conducted during the first two years after operation. Reoperation may improve survival in patients with recurrent gastric cancer.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Stomach Neoplasms / General Surgery / Retrospective Studies / Follow-Up Studies / Kaplan-Meier Estimate / Gastrectomy / Neoplasm Recurrence, Local Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Stomach Neoplasms / General Surgery / Retrospective Studies / Follow-Up Studies / Kaplan-Meier Estimate / Gastrectomy / Neoplasm Recurrence, Local Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2011 Type: Article