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Analysis of 89 amniotic samples using fluorescent in situ hybridization / 中华医学遗传学杂志
Article in Chinese | WPRIM | ID: wpr-237278
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the value of fluorescent in situ hybridization (FISH) for detecting common chromosome aneuploidies in interphase nuclei of amniotic fluid cells.</p><p><b>METHODS</b>Eighty two uncultured amniotic fluid samples and supernatants from 2 successfully and 5 unsuccessfully cultured amniotic fluid samples were analyzed with FISH. Results from standard cytogenetic analysis of 79 uncultured amniotic fluid samples and 2 successfully cultured amniotic fluid samples were compared with FISH results.</p><p><b>RESULTS</b>All of the 89 samples were succeeded analyzed with FISH. Positive findings included 3 cases with trisomy 21, 1 case with 47, XYY and 1 case with 69, XXX, which were consistent with results of karyotype analysis.</p><p><b>CONCLUSION</b>FISH is a rapid and accurate method for prenatal diagnosis, and can also provide a remedy to failed amniotic fluid cells culture.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Female / Humans / Pregnancy / In Situ Hybridization, Fluorescence / Cell Culture Techniques / Adult / Cell Biology / Amniotic Fluid / Karyotyping / Methods Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Female / Humans / Pregnancy / In Situ Hybridization, Fluorescence / Cell Culture Techniques / Adult / Cell Biology / Amniotic Fluid / Karyotyping / Methods Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2013 Type: Article