Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
Journal of Korean Medical Science
;
: 1062-1067, 2015.
Article
in English
| WPRIM
| ID: wpr-23733
ABSTRACT
The records of 63 high-risk neuroblastoma patients with bone marrow (BM) tumors at diagnosis were retrospectively reviewed. All patients received nine cycles of induction chemotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT). Follow-up BM examination was performed every three cycles during induction chemotherapy and every three months for one year after the second HDCT/auto-SCT. BM tumor cells persisted in 48.4%, 37.7%, 23.3%, and 20.4% of patients after three, six, and nine cycles of induction chemotherapy and three months after the second HDCT/auto-SCT, respectively. There was no difference in progression-free survival (PFS) rate between patients with persistent BM tumor and those without during the induction treatment. However, after tandem HDCT/auto-SCT, the PFS rate was worse in patients with persistent BM tumor than in those without (probability of 5-yr PFS 14.7% +/- 13.4% vs. 64.2% +/- 8.3%, P = 0.009). Persistent BM tumor during induction treatment is not associated with a worse prognosis when intensive tandem HDCT/auto-SCT is given as consolidation treatment. However, persistent BM tumor after tandem HDCT/auto-SCT is associated with a worse prognosis. Therefore, further treatment might be needed in patients with persistent BM tumor after tandem HDCT/auto-SCT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Antineoplastic Combined Chemotherapy Protocols
/
Retrospective Studies
/
Risk Factors
/
Treatment Outcome
/
Combined Modality Therapy
/
Bone Marrow Neoplasms
/
Stem Cell Transplantation
/
Induction Chemotherapy
/
Neoplasms, Multiple Primary
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2015
Type:
Article
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