A co-twin control study on birth weight, overweight and obesity among children younger than 18 years old in China / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the associations between birth weight and overweight/obesity among children.</p><p><b>METHODS</b>A total of 8 267 twin pairs younger than 18 years old from the Chinese National Twin Registry were included in the study. Associations between birth weight, childhood BMI and overweight/obesity were explored by this co-twin control study.</p><p><b>RESULTS</b>After adjusting for sex and zygosity, when birth weight had an increase of 0.5 kg per fold, the OR values for overweight and obesity were 1.87(95%CI 1.40-2.48) for 2-6 year olds, 1.69 (95%CI 1.16-2.46) for 6-12 year olds and 1.28 (95%CI 0.80-2.07) for 12-18 year olds.</p><p><b>RESULTS</b>from the stratified analysis in the 2-6 year-olds, statistically significant differences were seen. When birth weight increased 0.5 kg per fold, the risk of overweight and obesity increased by 0.87 times among the dizygotic twins, more than that of the monozygotic twins (OR=1.86, 95%CI1.24-2.81). The risk for male twins was 1.12 times higher than that of female twins (OR=1.65, 95%CI1.11-2.44).</p><p><b>CONCLUSIONS</b>Birth weight seemed associated with overweight and obesity for kids at early childhood or at age for schools. However, guidance on the implementation of public health interventions is still needed on these children.</p>