Noncanonical NF-κB pathway and hematological malignancies / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1069-1073, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-237593
ABSTRACT
Nuclear factor κB (NF-κB), including RelA, RelB, c-Rel, NF-κB1, and NF-κB2, plays a crucial role in immune response, inflammatory reaction, tumorigenesis, and development of peripheral lymphoid organs and lymphocytes. There are two NF-κB activation pathways canonical pathway (classical pathway) and noncanonical pathway (alternative pathway). Previous studies focused on the effects of the canonical NF-κB pathway (mainly p50-RelA) in hematological malignancies. Recently, the noncanonical NF-κB pathway (mainly p52-RelB) is gradually taken importance in pathogenesis of hematological malignancies. Understanding the relations of the noncanonical pathway with hematological malignancies would provide a new therapeutic approach for these diseases. This review focuses on the noncanonical NF-κB signaling transduction pathway and its relation to hematologic malignancies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
NF-kappa B
/
Hematologic Neoplasms
/
NF-kappa B p50 Subunit
/
NF-kappa B p52 Subunit
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article
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