Methylation status of zo-1 gene promoter in acute leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 863-865, 2010.
Article
in Zh
| WPRIM
| ID: wpr-237635
Responsible library:
WPRO
ABSTRACT
This study was purposed to investigate the difference of zo-1 gene promoter methylation between healthy individuals and acute leukemia patients. BS-PCR method was used to detect the status of zo-1 gene methylation in healthy individuals, acute leukemia patients and leukemic cell line NB4 cells. The results showed that zo-1 gene was hypomethylated in bone marrow samples from healthy individuals (1.9%). In newly diagnosed AL and relapsed patients, the rate of zo-1 gene methylation was 93.2% and 66.9% respectively, while it was 16.4% in AL patients in complete remission, which was much higher than that in healthy individuals. There was significant difference between them. It is concluded that as compared with healthy individuals, zo-1 gene in acute leukemia patients is hypermethylated and with different degrees in various phases of leukemia. Analysis of zo-1 gene methylation status may be useful to monitor the development of acute leukemia.
Full text:
1
Index:
WPRIM
Main subject:
Phosphoproteins
/
Leukemia
/
Acute Disease
/
Promoter Regions, Genetic
/
DNA Methylation
/
Cell Line, Tumor
/
Zonula Occludens-1 Protein
/
Genetics
/
Membrane Proteins
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article