Clonal expanded T-cell repertoire in MDS / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 793-797, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-237649
ABSTRACT
The myelodysplastic syndromes (MDS) comprises a heterogeneous group of clonal hematopoietic stem cell disorders, while immunological abnormalities are frequently observed in such patients. T-cell mediated suppression of hematopoietic precursors contributes to the cytopenia and is related to the initiation and development of myelodysplastic syndromes (MDS). In this review, current knowledge concerning the feature of T-cell clonal expansion in MDS based on the analysis of T-cell receptor repertoire is summarized, including following issues autoimmunity in MDS patients associated with T-cell mediated suppression of hematopoiesis, characteristics of T-cell clonal expansion in MDS patients, change of T-cell repertoire and recent thymus output function in MDS patients, efficiency of immunosuppressive treatment associated with T-cell clonal expansion in MDS patients and significance of T-cell clonal analysis in clinical application.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Myelodysplastic Syndromes
/
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
Clone Cells
/
Cell Biology
/
Allergy and Immunology
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article
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