Preparation and stability of β-carotene loaded using mesoporous silica nanoparticles as carriers system / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3579-3584, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-237671
ABSTRACT
1,3,5-Trimethylbenzene (1,3,5-TMB) was used as the pore-enlarging modifier to expand the pore size of MCM-41 (mobil company of matter) mesoporous silica nanoparticles. The solvent impregnation method was adopted to assemble non-water-soluble β-carotene into the pore channel of MCM-41. The MCM-41 and drug assemblies were characterized by TEM, FT-IR, elemental analysis and N2 adsorption-desorption. The results showed that MCM-41 has good sphericity and regular pore structure. The research also investigated the optimal loading time, the drug loading and the vitro stability of the β-carotene. As a drug carrier, the modified MCM-41 showing a shorter drug loading time, the drug loading as high as 85.58% and the stability of β-carotene in drug assemblies has improved. The study of this new formulation provides a new way for β-carotene application.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drug Carriers
/
Chemistry
/
Drug Delivery Systems
/
Silicon Dioxide
/
Beta Carotene
/
Drug Stability
/
Nanoparticles
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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