ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus / 당뇨병
Korean Diabetes Journal
; : 320-326, 2010.
Article
in En
| WPRIM
| ID: wpr-23769
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients. METHODS: The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified. RESULTS: The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959). CONCLUSIONS: The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pyrophosphatases
/
Cardiovascular Diseases
/
Calcium
/
Prevalence
/
Lifting
/
Phosphoric Diester Hydrolases
/
Diphosphates
/
Coronary Vessels
/
Diabetes Mellitus, Type 2
/
Genotype
Type of study:
Prevalence_studies
/
Prognostic_studies
Limits:
Aged
/
Humans
Language:
En
Journal:
Korean Diabetes Journal
Year:
2010
Type:
Article