Development and characterization of TPGS modified proniosomes of docetaxel / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3775-3779, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-237732
ABSTRACT
A novel oral delivery system that TPGS modified docetaxel proniosomes, DTX-TPGS-PN, was developed and the characterization after hydration was observed. Firstly, Doce-TPGS-PN was optimized by investing the factors, including the type of surfactant, methods of adding TPGS, content of TPGS and the molar ratio of span40/cholesterol, which may affecting the particle size, encapsulation efficiency and instantaneous release of drug in the formulation. Then, the morphology, particle size, Zeta potential, encapsulation efficiency and in vitro release of the formulation were evaluated. The result showed that hydrated nanoparticles of DTX-TPGS-PNs were (93 ± 6.5) nm in size,(-83.95 ± 3.69) mV in zeta potential, (97.31 ± 0.60)% in encapsulation efficiency, exhibiting spherical morphology and biphasic release process that a low burst effect within the first 0.5 hour and a relative-sustained release for the next several hours in PBS. These results indicate the oral delivery system of DTX-TPGS-PN was successfully built with good properties.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Pharmacology
/
Polyethylene Glycols
/
Vitamin E
/
Chemistry
/
Chemistry, Pharmaceutical
/
Taxoids
/
Methods
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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