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Study on mechanism for anti-hyperlipidemia efficacy of rhubarb through assistant analysis systems for acting mechanisms of traditional Chinese medicine / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3703-3708, 2015.
Article in Chinese | WPRIM | ID: wpr-237745
ABSTRACT
Rhubarb is a traditional Chinese medicine (TCM), wildly used in treating the disease of hyperlipidemia. However, its components are complicated, so that it is still difficult to clear the specific roles of its various components in blood lipids regulation in. So we decide to systematically study the anti- hyperlipidemia mechanism of rhubarb. We integrated multiple databases, based on entity grammar systems model, constructed molecular interaction network between the chemical constituents of rhubarb and hyperlipidemia. The network includes 231 nodes and 638 edges. Thus we infer the interactions of active targets and disease targets to clarify the anti-hyperlipidemia mechanism. And find that rhubarb can promote excretion of cholesterol; inhibit clotting factors and improve blood circulation; inhibit the release of inflammatory cytokines and maintain fat metabolism balance; inhibit cholesterol and triglyceride synthesis; and other ways to achieve lipid-lowering effect. Thus this study provides reference for novel drug development and component compatibility, and also gives a new way for the systematically study of acting mechanism of traditional Chinese medicine.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Rheum / Drugs, Chinese Herbal / Signal Transduction / Chemistry / Databases, Factual / Drug Therapy / Lipid Metabolism / Gene Regulatory Networks / Genetics / Hyperlipidemias Type of study: Prognostic study Limits: Animals / Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rheum / Drugs, Chinese Herbal / Signal Transduction / Chemistry / Databases, Factual / Drug Therapy / Lipid Metabolism / Gene Regulatory Networks / Genetics / Hyperlipidemias Type of study: Prognostic study Limits: Animals / Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article