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Electrochemotherapy and its mechanism for sarcoma of KM mice / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 914-917, 2005.
Article in Chinese | WPRIM | ID: wpr-238312
ABSTRACT
In this paper are analyzed the effect of electrochemotherapy and its mechanism. The favorable parameter of electric pulses (EP) was studied in vitro using the S-180 cells exposed to various EP. After the tumor model was copied, the tumor-bearing mice were randomly divided into four groups control, chemotherapy, electrotherapy, and electrochemotherapy. The tumor inhibitory ratio, the cure ratio and the level of oxygen free radicals (OFR) were determined. The inhibitory ratio and cure ratio of electrochemotherapy group were significantly higher than those in the chemotherapy, electrotherapy and control groups (P < 0.05). The injury of OFR was decreased while the immunological competence was increased. The mechanism of electrochemotherapy may be related with the enhancement of cell membranepermeability, the depression of drug resistance, the improvement of immunological competence, and so on.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sarcoma 180 / Therapeutics / Bleomycin / Random Allocation / Electric Stimulation Therapy / Drug Delivery Systems / Electroporation / Electrochemistry / Methods / Antineoplastic Agents Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sarcoma 180 / Therapeutics / Bleomycin / Random Allocation / Electric Stimulation Therapy / Drug Delivery Systems / Electroporation / Electrochemistry / Methods / Antineoplastic Agents Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2005 Type: Article