Impedance effects of interleukin-6 on cyclophosphamide-induced hematopoietic damnification in dogs / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 798-801, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-238338
ABSTRACT
The aim of this study is to evaluate the effect of Interleukin-6 on cyclophosphamide-induced hematopoietic damnification. The doses of Interleukin-6 in 3 different regimens were hypodermally injected into dogs for 7 days respectively to establish the cyclophosphamide-induced hematopoietic damnification model. The effect of Interleukin-6 on the production of platelets and the amount of other cells in the dogs' bone marrow were determined on the 21st day. The results showed that Interleukin-6 significantly alleviated the reduction of platelet count and recovered the platelets level faster. The impedance effects of Interleukin-6 directed against hematopoietic damnification of bone marrow and spleen were shown by pathological examination. These suggest that the Interleukin-6 can significantly impede cyclophosphamide-induced hematopoietic damnification.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Thrombocytopenia
/
Bone Marrow Cells
/
Interleukin-6
/
Cyclophosphamide
/
Therapeutic Uses
/
Leukopenia
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2005
Type:
Article
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