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HFE genetic variability and risk of alcoholic liver disease: A meta-analysis / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 626-633, 2016.
Article in English | WPRIM | ID: wpr-238456
ABSTRACT
Studies examining the association of hemochromatosis (HFE) gene polymorphisms and susceptibility to alcoholic liver disease (ALD) yielded inconsistent results. Thus, we performed a metaanalysis to investigate whether the variations in HFE gene increase the risk of ALD. The studies published up to Feb. 2014 were identified by searching PubMed/MEDLINE, ISI Web of Science, EMBASE and China National Knowledge Infrastructure databases, which was complemented by screening the references of the retrieved studies. For all genotypes and alleles, the odds ratios (ORs) with 95% confidence intervals (CIs) according to the heterogeneity were pooled using fixed-effect model. Sixteen studies with 1933 cases and 9874 controls were included for this meta-analysis. C282Y/C282Y, C282Y/wild type, H63D/wild type and C282Y/H63D were found not to be associated with susceptibility to ALD, but increased risk of H63D/H63D (OR 1.52, 95% CI 1.05-2.22, P=0.029) was observed for ALD when compared to total control. Comparison of ALD patients with alcoholics without liver damage revealed a significant association of D allele, as well as a marginal association of H63D/wild type with ALD, while H63D/H63D was not significantly associated with ALD although increased value of OR was obtained. The presence of Y allele and other genotypes yielded insignificant findings when ALD patients were compared with alcoholics without liver damage. No evident publication bias or significant heterogeneity among studies was detected in this meta-analysis. In conclusion, our metaanalysis showed a marginal higher prevalence of H63D variant in ALD but did not support an increased risk of C282Y mutation.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Alleles / Genetic Association Studies / Hemochromatosis Protein / Genetics / Genotype / Liver Diseases, Alcoholic / Mutation Type of study: Etiology study / Prognostic study / Systematic reviews Limits: Humans Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Alleles / Genetic Association Studies / Hemochromatosis Protein / Genetics / Genotype / Liver Diseases, Alcoholic / Mutation Type of study: Etiology study / Prognostic study / Systematic reviews Limits: Humans Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2016 Type: Article