Porcine MSC-derived CLC induced by rabbit's cardiomyocytes extract did not induce immune reaction in vivo / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 929-931, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-238489
ABSTRACT
<p><b>OBJECTIVE</b>To compare the in vivo immune reaction of transplanting porcine MSC-derived CLC with rabbit cardiomyocytes extracts induced differentiation or in vitro cultured porcine MSC.</p><p><b>METHODS</b>After injecting the MSC-derived CLC or MSC to the original porcines, the number of CD4+, CD8+ T cells were determined by flow cytometry. The serum concentrations of IL-2, IL-4 were measured by ELISA, and the porcine spleen lymphocyte CTL cytotoxicity was determined by Cell Counting Kit-8 Assay.</p><p><b>RESULTS</b>The numbers of CD4+ and CD8+ T cells, the serum concentrations of IL-2, IL-4 and spleen lymphocyte CTL cytotoxicity were all similar in porcines received MSC-derived CLC induced by rabbit's CMs extract or MSC transplantation.</p><p><b>CONCLUSION</b>The porcine MSC-derived CLC induced by rabbit's CMs extract did not induce extra immune reaction when injected back to the original porcine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swine
/
Swine, Miniature
/
Bone Marrow Cells
/
CD4 Antigens
/
Bone Marrow Transplantation
/
CD4-CD8 Ratio
/
CD8 Antigens
/
Cell Biology
/
Myocytes, Cardiac
/
Allergy and Immunology
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2006
Type:
Article
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