The role of cyclooxygenase on angiogenesis and endothelial progenitor cell mobilization in rat ischemic myocardium / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 833-836, 2006.
Article
in Zh
| WPRIM
| ID: wpr-238506
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of COX1 and COX2 on angiogenesis and endothelial progenitor cell mobilization in rats with experimental myocardial infarction (MI).</p><p><b>METHODS</b>The rats were randomly divided into 3 groups: MI group, MI plus rofecoxib group and MI plus valeryl salicylate group. At the 7th day after operation, circulating EPCs, plasma VEGF and HIF-1alpha mRNA of ischemic myocardium were measured. At the 28th day post operation, capillary densities were also measured in ischemic myocardium.</p><p><b>RESULT</b>Compared with the MI group and the MI plus valeryl salicylate group, circulating EPCs, plasma VEGF, HIF-1alpha mRNA and capillary densities of ischemic myocardium were all decreased in MI plus rofecoxib group.</p><p><b>CONCLUSION</b>The present study revealed that COX2 play an important role with angiogenesis and endothelial progenitor cell mobilization in rat with experimental MI by modulating expression of VEGF and HIF-1alpha.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Pharmacology
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Stem Cells
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Blood
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Random Allocation
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Cyclooxygenase Inhibitors
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Rats, Sprague-Dawley
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Neovascularization, Physiologic
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Cell Biology
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Endothelial Cells
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2006
Type:
Article