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Pharmacokinetics of scutellarin and its derivant scutellarin ethyl ester in rats / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-238589
Responsible library: WPRO
ABSTRACT
To develop a HPLC method for determination of the concentration of scutellarin and scutellarin ethyl ester and their pharmacokinetics were also compared. 104 mg kg-1of scutellarin or 114. 5 mg kg-1 scutellarin ethyl ester were given at single dose by oral gavarge. Blood samples were collected from the jugular vein. Plasma concentration was measured by HPLC. The pharmacokinetic parameters were calculated with Winnonlin program. The plasma concentration-time profile of scutellarin and scutellarin ethyl ester were both fitted with non-compartment model and both were double peaks. The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1. The speed ingested into the blood of scutellarin ethyl ester was faster than scutellarin, and the bioavailability of scutellarin ethyl ester was two times higher than scutellarin.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats / Male / Pharmacokinetics / Chromatography, High Pressure Liquid / Rats, Wistar / Glucuronides / Flavones / Apigenin / Glucuronates / Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats / Male / Pharmacokinetics / Chromatography, High Pressure Liquid / Rats, Wistar / Glucuronides / Flavones / Apigenin / Glucuronates / Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article