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Study on effect of combined application on distribution of gastrodigenin in rats / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3368-3372, 2013.
Article in Chinese | WPRIM | ID: wpr-238590
ABSTRACT
To determine the concentration of gastrodigenin in tissue homogenates with high performance liquid chromatography (HPLC) , in order to study the changes of the distribution of gastrodigenin before and after combined application in rat tissues, including heart, liver, spleen, lung, kidney and brain tissues. The study showed that gastrodigenin could be found in kidney, liver, heart, lungs, spleen and brain tissues. After the combined application of Gastrodiae Rhizoma and Ligustici Wallichii Rhizoma, the content of gastrodigenin decreased in kidney and liver to varying degrees, while increasing in lung and brain. This indicated that Ligustici Wallichii Rhizoma had certain impact on the in vivo distribution of gastrodigenin, an active ingredient in Gastrodiae Rhizoma, because it could improve gastrodigenin's distribution in lung and brain tissues. The study provides scientific basis for the combined application of Gastrodiae Rhizoma and Ligustici Wallichii Rhizoma in treating brain diseases.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Spleen / Benzyl Alcohols / Brain / Pharmacokinetics / Chemistry / Chromatography, High Pressure Liquid / Ligusticum / Gastrodia / Kidney / Liver Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spleen / Benzyl Alcohols / Brain / Pharmacokinetics / Chemistry / Chromatography, High Pressure Liquid / Ligusticum / Gastrodia / Kidney / Liver Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article