Effect of stability and dissolution of realgar nano-particles using solid dispersion technology / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To improve the stability and dissolution of realgar nano-particles by solid dispersion.</p><p><b>METHOD</b>Using polyethylene glycol 6000 and poloxamer-188 as carriers, the solid dispersions were prepare by melting method. XRD, microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As(2)0(3) were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions.</p><p><b>RESULT</b>The results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly, the reunion of realgar nano-particles and content of As(2)0(3) were reduced for the formation of solid dispersions.</p><p><b>CONCLUSION</b>The solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability, dissolution and solubility.</p>