: Synthesis of some derivatives of 1, 3, 4-thiodiazol for preparing the diuretic drug acetazolamide

ABSTRACT

The acetazolamide was prepared from hydrazine sulfate and ammonium or potasium thiocy anate via the hydrazodicarbothiamide and 2,2-diamino-1,3,4-thiadiazole-5, 5-disulfide (DTD). From DTD by acetylation, chlorosulfoxidation sulfonamidation, acetazolamide was obtained. The effects of the molecular of reagents, solvent, and catalysts and the reaction time were studied in order to find the best condition for synthesis of these compounds. We found acetone as a catalytic agent for preparation of hydrazodicacbo thiamide. The result showed that the yield increased by one and a half time more than that without acetone. We also exposed the explanation for the catalytic role of acetone on increasing the yield of hydrazodicarbothiamide preparation.