A phase II multicenter study to investigate R-ICE as a salvage therapy for relapsed diffuse large B-cell lymphoma / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 314-317, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-238824
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and safety of rituximab together with etoposide, carboplatin, and ifosfamide (R-ICE) as a salvage therapy for relapsed diffuse large B-cell lymphoma (DLBCL) after treatment with rituximab based first-line chemotherapy (R-Chemo).</p><p><b>METHODS</b>DLBCL patients with complete remission (CR) or complete remission unconfirmed (CRu) after 6-8 cycles of R-Chemo treatment but relapsed for first time after stopping treatment were included in this study. Three cycles of R-ICE regimen were given to the patients [1st day rituximab, 375 mg/m²; 2nd-4th day ifosfamide, 1 600 mg/m²; 3rd day carboplatin, area under the curve (AUC) =5 (maximum dosage 800 mg), 2nd-4th day etoposide, 100 mg/m²]. The primary endpoint was overall response rate (ORR). The secondary endpoints were the 2-year progression-free survival (PFS), 2-year overall survival (OS), and toxicity.</p><p><b>RESULTS</b>Thirty-two patients with median age at 55(range 26-68) were recruited in this clinical study and the final analysis. After three cycles of R-ICE salvage treatment, 16 patients (50.0%) achieved CR or CRu and 9 patients (28.1 %) achieved partial remission (PR). The ORR was 78.1%. The 2-year PFS and OS were 40.8% and 60.7%, respectively. Nineteen patients (59.4%) had 3/4 grade adverse events. The ratios of leukopenia neutropenia, anemia and thrombocytopenia in patients with 3/4 grades were 37.5%, 15.6%, and 37.5%, respectively. No patient died.</p><p><b>CONCLUSION</b>R-ICE is an effective salvage therapy for R-Chemo relapsed DLBCL with manageable toxicities.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Therapeutics
/
Antineoplastic Combined Chemotherapy Protocols
/
Lymphoma, Large B-Cell, Diffuse
/
Salvage Therapy
/
Therapeutic Uses
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2014
Type:
Article
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