Expression of PIM-1 in prostate cancer tissue and its relationship with PSA recurrence / 中华男科学杂志
National Journal of Andrology
;
(12): 323-326, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-238957
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of the PIM-1 protein in prostate cancer tissue and its relationship with PSA recurrence.</p><p><b>METHODS</b>We used the immunohistochemical SP method to detect the expression of the PIM-1 protein in the prostate tissues of 68 cases of prostate cancer (PCa) and 37 cases of benign prostatic hyperplasia (BPH).</p><p><b>RESULTS</b>The positive rate of the PIM-1 protein expression was 67.65% (46/68) in the PCa tissue, significantly higher than 40.54% (15/37) in the BPH tissue (P<0.05). Its positive rates in PCa Gleason scores 6, 7 and 8-10 were 33.33% (7/21), 77.5% (21/28) and 94.74% (18/19), respectively, with significant between-group differences (P<0.05), and those in stages I , II, III and IV of PCa were 47.62%, 53.85%, 73.33% and 94.74%, respectively. Kaplan-Meier analysis of the results of a 36-month follow-up showed the ratios of PIM-1 expression to PSA recurrence and non-recurrence were 10/22 (45.45%) and 36/46 (78.26%), respectively, with statistically significant differences (P<0.05).</p><p><b>CONCLUSION</b>PIM-1 protein expression in PCa tissue is closely related to the Gleason score and clinical stage of PCa and PSA recurrence, which suggests that the PIM-1 gene plays an important role in PCa evolution and progression, and may be an indicator for the prognosis of PCa.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Proto-Oncogene Proteins c-pim-1
/
Metabolism
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2012
Type:
Article
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