Desert hedgehog regulates the proliferation and differentiation of Leydig cells: an update / 中华男科学杂志
National Journal of Andrology
;
(12): 172-175, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-238966
ABSTRACT
Hedgehog signaling pathway plays an important role in regulating the development of endocrine glands. Desert hedgehog (Dhh) has become a recent focus for its regulation of testis development, especially of Leydig cells. Dhh, as a Sertoli cell product, regulates the proliferation and differentiation of Leydig cell lineage and functions to secrete testosterone through a paracrine signaling mechanism. Testosterone, as the most important sex hormone of the male, plays a critical role in testis development, spermatogenesis and maintenance of normal masculinization. Therefore, normal Dhh signaling pathway ensures normal spermatogenic function. Researches on the Hedgehog signaling pathway in the testis have a potential significance for studying the pathophysiological mechanisms of androgen deficiency and dyszoospermia, as well as for the clinical treatment of these diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatogenesis
/
Testis
/
Signal Transduction
/
Cell Differentiation
/
Cell Biology
/
Cell Proliferation
/
Hedgehog Proteins
/
Leydig Cells
/
Metabolism
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2012
Type:
Article
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