The correlation between platelet parameters and acute rejection after renal transplantation / 南方医科大学学报
Journal of Southern Medical University
;
(12): 413-416, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-239166
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between acute graft rejection early after renal transplantation and the variations of platelet parameters.</p><p><b>METHODS</b>We retrospectively analyzed the clinical data of 167 renal transplant recipients before and within 2 months after the surgery. Before and at 1-10 days, 15 days, 30 days, 45 days and 60 days after the transplantation, 5 platelet parameters, including platelet count (PLT), platelet hematocrit (PCT), mean platelet volume (MPV), platelet volume distribution width (PDW), and large platelet ratio (P-LCR), were detected in the 35 patients with acute graft rejection within two months (AR group) and in the other 132 recipients with good graft recovery (control group).</p><p><b>RESULTS</b>The AR group and control group showed no significant difference in PLT, PCT, MPV, or P-LCR before the surgery, but the PDW was significantly higher in the AR group (t=2.18, P=0.035). These parameters were similar within 5 postoperative days between the two groups (P>0.05), but in postoperative days 6-15, the AR group showed significantly increased MPV, PDW and P-LCR compared with the control group (P<0.05). In postoperative days 6-9, MPV, PDW and P-LCR became stable in AR group but tended to decrease in the control group, showing obviously different patterns of variation between the two groups (P<0.05).</p><p><b>CONCLUSIONS</b>Preoperative PDW may have a positive correlation with acute graft rejection after renal transplantation. Monitoring the variations of MPV, PDW and P-LCR may help in the diagnosis of acute graft rejection early after renal transplantation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Blood
/
Blood Platelets
/
Retrospective Studies
/
Kidney Transplantation
/
Cell Biology
/
Graft Rejection
/
Hematologic Tests
Type of study:
Observational study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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