Research progress in the correlation between insulin resistance and pulmonary arterial hypertension / 南方医科大学学报
Journal of Southern Medical University
;
(12): 301-305, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-239190
ABSTRACT
Pulmonary arterial hypertension (PAH) is a common clinical syndrome characterized by dysfunction of pulmonary arterioles leading to increased vascular resistance and elevated pulmonary artery pressure. Insulin resistance (IR) is recognized as a critical risk factor for cardiovascular disease, but recent evidence suggested an association between IR and PAH. The pathological consequences of IR, such as hyperinsulinemia, dyslipidemia, chronic inflammation, and oxidative stress can cause pulmonary vasoconstriction, endothelial dysfunction and vascular remodeling, which aggravate the progressive course of PAH. Therefore, addressing the molecular mechanisms by which IR promotes the development of pulmonary hypertension and searching for appropriate interventions are important in the management of PAH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vasoconstriction
/
Insulin Resistance
/
Oxidative Stress
/
Hypertension
/
Hypertension, Pulmonary
/
Inflammation
/
Lung
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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