Diagnosis and prenatal diagnosis to a family of hemoglobin variant with α-thalassemia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 226-228, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-239499
ABSTRACT
<p><b>OBJECTIVE</b>Diagnosis and prenatal diagnosis to a family of hemoglobin variant with α-thalassemia.</p><p><b>METHODS</b>Whole blood cell analysis, hemoglobin analysis by capillary zone electrophoresis (CZE), Gap-PCR, polymerase chain reaction-reverse dot blot (PCR-RDB) assay and DNA sequencing.</p><p><b>RESULTS</b>Hb Zurich Albisrieden with α°-thalassemia lead to severe anemia. The genotype of fetus is also Hb Zurich Albisrieden with α°-thalassemia.</p><p><b>CONCLUSION</b>Abnormal hemoglobin with α-thalassemia may lead to severe anemia, Prenatal diagnosis of thalassemia has the vital significance for eugenic birth.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prenatal Diagnosis
/
Blood
/
Hemoglobins, Abnormal
/
Molecular Sequence Data
/
Base Sequence
/
Embryology
/
Alpha-Thalassemia
/
Diagnosis
/
Fetal Diseases
/
Genetics
Type of study:
Diagnostic study
Limits:
Adult
/
Child, preschool
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Type:
Article
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