SNP microarray analysis of retention abortion chorionic villus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 180-182, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-239510
ABSTRACT
<p><b>OBJECTIVE</b>To compare villus cell culture and karyotype analysis with single nucleotide polymorphism (SNP) microarray technology for the detection of chorionic villus chromosome in patients with retention of abortion.</p><p><b>METHODS</b>Forty cases were analyzed with the two methods.</p><p><b>RESULTS</b>Chorionic villus culturing was successful in 29 cases, among which 10 were found to have an abnormal karyotypes. For the SNP microarray analysis, all 40 cases were successful, among which 16 were shown to have an abnormal molecular karyotype.</p><p><b>CONCLUSION</b>SNP microarray technology is highly accurate and specific, which is particularly suitable for the detection of chromosomal deletions or duplications, uniparental disomy, low-percentage mosaicism and other chromosomal abnormalities. It has provided an effective supplement to the conventional chorionic villus culture and karyotype analysis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Trimester, First
/
Chemistry
/
Chorionic Villi
/
Chromosome Aberrations
/
Abortion, Missed
/
Oligonucleotide Array Sequence Analysis
/
Polymorphism, Single Nucleotide
/
Genetics
/
Karyotyping
/
Methods
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Type:
Article
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