Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 89-93, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-239527
ABSTRACT
<p><b>OBJECTIVE</b>To investigate association between the lysyl oxidase-like 1 (LOXL1) gene single nucleotide polymorphism (SNP) and primary open-angle glaucoma (POAG) in Sichuan population.</p><p><b>METHODS</b>In this study,416 subjects with primary open-angle glaucoma and 997 normal controls were recruited.Three reported LOXL1 tag SNPs (rs1048661,rs3825942 and rs2165241) were genotyped by SNaPshot method.</p><p><b>RESULTS</b>The study showed that the genotypes of LOXL1 rs1048661,rs3825942 and rs2165241 between POAG and control groups were not statistically significant (OR=1.085, 95%CI 0.92-1.28, P=0.578 for rs1048661; OR=1.059, 95%CI 0.82-1.37, P=0.846 for rs3825942; OR=1.006, 95%CI 0.77-1.32, P=0.966 for rs2165241, respectively). There were no significant difference in allele frequency distribution of LOXL1 rs1048661、rs3825942 and rs2165241 between POAG and normal controls (P=0.322, P=0.660, P=0.965).</p><p><b>CONCLUSION</b>The results from the present study do not indicate the association of LOXL1 SNPs (rs1048661, rs3825942 and rs2165241) with POAG in Sichuan population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Glaucoma, Open-Angle
/
Polymorphism, Single Nucleotide
/
Asian People
/
Genetics
/
Amino Acid Oxidoreductases
Limits:
Adult
/
Aged
/
Aged80
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Type:
Article
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