The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1458-1461, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-239645
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract.</p><p><b>METHOD</b>The blood sample were obtained at 0,0.083,0.5,1,1.5,2,3,4,5,7,10 h after a single dose oral administration of rhubarb (50 mg x kg(-1)). The plasma rhein concentration was determined by HPLC. The pharmacokinetics of rhein were analysed by 3P97 program.</p><p><b>RESULT</b>The absorption of rhein was very fastafter oral administration of rhubarb extract in the healthy volunteers. The main pharmacokinetic parameters of rhein were C(max) (3.20 +/- 1.08) microg x mL(-1); t(max) (1.03 +/- 0.41) h; t(1/2alpha) (0.21 +/- 0.02) h; t(1/2beta) (2.68 +/- 1.09) h; MRT(5.31 +/- 1.78) h; AUC(0-infinity) (1 573.08 +/- 366.48) microg x mL(-1) min(-1), respectively.</p><p><b>CONCLUSION</b>Rhein could be absorbed rapidly and its pharmacokinetics was consistent with two-compartment model.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Rheum
/
Blood
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Administration, Oral
/
Chromatography, High Pressure Liquid
/
Anthraquinones
/
Area Under Curve
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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