Studies on immunoregulation of polysaccharides-la from Radix Cynanchi Bungei / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1352-1355, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-239685
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of PRCB1a (one component of polysaccharides from Radix Cynanchi Bungei) on transformation of T lymphocytes of rabbit in vitro and immune function in mice.</p><p><b>METHOD</b>Three doses of PRCB1a (2,4,6 g x L(-1)) were respectively put in bottle with PHA and blood of rabbit. The effect of PRCB1a on immunity in vitro was studied by observing transformation of T lymphocytes; The dosage of PRCB1a (50,100,150 mg x kg(-1) x d(-1)) was given orally for seven days. The effects on immune function were investigated in mice.</p><p><b>RESULT</b>Three doses of PRCB1a could significantly promote (P < 0.01) the ability of T lymphocytes proliferation; PRCB1a could improve the mouse thymus and spleen index, the celiac macrophage ability of engulfing CRBC, the delayed type hypersensitivity ability and the macrophage engulfing carbon granula ability.</p><p><b>CONCLUSION</b>The results indicate PRCB1a can enhance nonspectific and specific cellular immune function.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Polysaccharides
/
Drugs, Chinese Herbal
/
Lymphocyte Activation
/
T-Lymphocytes
/
Random Allocation
/
Chemistry
/
Adjuvants, Immunologic
/
Plant Roots
/
Cynanchum
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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