Methodological studies on selectively removing toxins in Aristolochiae manshuriensis by chinese processing techniques / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1243-1246, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-239713
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the possibility of selectively detoxifying aristolochic acids in Aristolochiae manshuriensis (Guanmutong) by the chemical properties of aristolochic acids and traditional Chinese processing experience.</p><p><b>METHOD</b>The technical parameters in processing technique of A. manshuriensis were optimized by orthogonal designed methods with aristolochic acid A.</p><p><b>RESULT</b>The processing technique was soaked in 0.1 mol x L(-1) baking soda for several times and then processing with vinegar. Temperature was important factor to detoxify aristolochic acids. aristolochic acid A were removed over 90% from A. manshuriensis in laboratory and over 80% in medium-scale production by 10 batches from two origins of botanical drugs with different contents, and decreased to 0.35-0.60 mg x g(-1) in processed products. aristolochic acid A existed mostly salt-forms in the botanical drug.</p><p><b>CONCLUSION</b>Most toxic components in Guanmutong could be removed by the new processing method.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Temperature
/
Chemistry
/
Technology, Pharmaceutical
/
Sodium Bicarbonate
/
Plant Stems
/
Acetic Acid
/
Pharmaceutical Solutions
/
Aristolochia
/
Aristolochic Acids
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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