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Methodological studies on selectively removing toxins in Aristolochiae manshuriensis by chinese processing techniques / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1243-1246, 2005.
Article in Chinese | WPRIM | ID: wpr-239713
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the possibility of selectively detoxifying aristolochic acids in Aristolochiae manshuriensis (Guanmutong) by the chemical properties of aristolochic acids and traditional Chinese processing experience.</p><p><b>METHOD</b>The technical parameters in processing technique of A. manshuriensis were optimized by orthogonal designed methods with aristolochic acid A.</p><p><b>RESULT</b>The processing technique was soaked in 0.1 mol x L(-1) baking soda for several times and then processing with vinegar. Temperature was important factor to detoxify aristolochic acids. aristolochic acid A were removed over 90% from A. manshuriensis in laboratory and over 80% in medium-scale production by 10 batches from two origins of botanical drugs with different contents, and decreased to 0.35-0.60 mg x g(-1) in processed products. aristolochic acid A existed mostly salt-forms in the botanical drug.</p><p><b>CONCLUSION</b>Most toxic components in Guanmutong could be removed by the new processing method.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Temperature / Chemistry / Technology, Pharmaceutical / Sodium Bicarbonate / Plant Stems / Acetic Acid / Pharmaceutical Solutions / Aristolochia / Aristolochic Acids Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Temperature / Chemistry / Technology, Pharmaceutical / Sodium Bicarbonate / Plant Stems / Acetic Acid / Pharmaceutical Solutions / Aristolochia / Aristolochic Acids Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2005 Type: Article