Control of demyelination for recovery of spinal cord injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 306-310, 2008.
Article
in English
| WPRIM
| ID: wpr-239829
ABSTRACT
Since loss of oligodendrocytes and consequent demyelination of spared axons severely impair the functional recovery of injured spinal cord, it is reasonably expected that the reduction of oligodendroglial death and enhanced remyelination of demyelinated axons will have a therapeutic potential to treat spinal cord injury. Amelioration of axonal myelination in the injured spinal cord is valuable for recovery of the neural function of incompletely injured patients. Here, this article presents an overview about the pathophysiology and mechanism of axonal demyelination in spinal cord injury and discusses its therapeutic significance in the treatment of spinal cord injury. Moreover, it further introduces the recent strategies to improve the axonal myeliantion to facilitate functional recovery of spinal cord injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord Injuries
/
Therapeutics
/
Demyelinating Diseases
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2008
Type:
Article
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