Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis: a meta-analysis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3477-3482, 2014.
Article
in English
| WPRIM
| ID: wpr-240142
ABSTRACT
<p><b>BACKGROUND</b>Several previous studies have shown that diffusion-weighted imaging (DWI) can provide additional information for focal pancreatic lesions by demonstrating more restricted diffusion in solid malignant tumors than in chronic pancreatitis, which can be indicated by a decreased apparent diffusion coefficient (ADC). However, these studies have a modest sample size and convey inconclusive results. The aim of this study was to determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted magnetic resonance imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis.</p><p><b>METHODS</b>We determined the sensitivities and specificities across studies. A summary receiver operator characteristic (sROC) curve was constructed to calculate the area under the curve (AUC).</p><p><b>RESULTS</b>The pooled sensitivity of DWI was 0.86 (95% CI 0.80-0.91) and the pooled specificity was 0.82 (95% CI 0.72-0.89). The AUC of the sROC was 0.91 (95% CI 0.88-0.93).</p><p><b>CONCLUSIONS</b>DWI may be a potentially technically feasible tool for differentiating pancreatic carcinoma from mass-forming chronic pancreatitis. However, large-scale randomized control trials are necessary to assess its clinical value.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatic Neoplasms
/
Diffusion Magnetic Resonance Imaging
/
Diagnosis
/
Pancreatitis, Chronic
/
Methods
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Prognostic study
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2014
Type:
Article
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