Pharmacological action and mechanisms of ginkgolide B / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 922-928, 2007.
Article
in English
| WPRIM
| ID: wpr-240303
ABSTRACT
<p><b>OBJECTIVE</b>To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating factor", and "pharmacological". Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected.</p><p><b>RESULTS</b>The key issues related to the pharmacological actions and mechanisms of ginkgolide B were summarized. The ginkgolide B possesses a number of beneficial effects such as anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects. Meantime, their mechaniams were discussed.</p><p><b>CONCLUSIONS</b>The Ginkgolide B is the most potent antagonist of platelet activating factor (PAF) and exhibits therapeutic action in a variety of diseases mainly by the PAF receptor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatitis
/
Pharmacology
/
Reperfusion Injury
/
Chemistry
/
Acute Disease
/
Neuroprotective Agents
/
Anti-Asthmatic Agents
/
Ginkgolides
/
Drug Therapy
/
Lactones
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2007
Type:
Article
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