The experimental study of mechanism of integrin in hypertrophic scar contracture / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 38-40, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-240390
ABSTRACT
<p><b>OBJECTIVE</b>To study the mechanism of integrin in hypertrophic scar.</p><p><b>METHODS</b>Fibroblasts from 10 samples of human hypertrophic scars was cultured, FQ-PCR assay was applied to detect mRNA expression of alpha-SMA in hypertrophic scar fibroblasts after integrin and FAK antibody blocking.</p><p><b>RESULTS</b>mRNA of alpha-SMA in fibroblasts expressed obviously lower after integrin and FAK antibody blocking than that of control groups ( P < 0.05).</p><p><b>CONCLUSION</b>Through accelerating the synthesis of alpha-SMA, integrin and FAK play an important role in contracture of hypertrophic scar.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Integrins
/
Cells, Cultured
/
Actins
/
Cicatrix, Hypertrophic
/
Contracture
/
Focal Adhesion Kinase 1
/
Fibroblasts
/
Metabolism
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2006
Type:
Article
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