Differential display of homeobox gene expressions in the normal, wounded human fetal and adult skins by DNA microarray / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 372-374, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-240420
ABSTRACT
<p><b>OBJECTIVE</b>To explore the differential expression of homeobox genes in the normal, wounded human fetal and adult skins and its significance in fetal scarless healing.</p><p><b>METHODS</b>Gene chips containing 14 000 human genes were used to investigate homeobox gene expressions of the normal, wounded human fetal and adult skins.</p><p><b>RESULTS</b>There were significant differences between the expression of homeobox genes, especially for PRX-2, HOXB13, HOXB6 and HOXB7.</p><p><b>CONCLUSIONS</b>The homeobox gene is in close relation to developmental biology. The different expressions and changes of homeobox genes in the normal, wounded human fetal and adult skin may be a primary cause of different wound healing between fetal and adult skin.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Wound Healing
/
Gene Expression
/
Cells, Cultured
/
Genes, Homeobox
/
Homeodomain Proteins
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Fetus
/
Genetics
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2005
Type:
Article
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