Genotyping of HBV DNA in Shenzhen and clinical manifestations / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 199-200, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-240440
ABSTRACT
<p><b>OBJECTIVE</b>To detect HBV DNA and its genotypes.</p><p><b>METHODS</b>The 6 isoforms of HBV DNA was detected out using of different probes by Polymerase Chain Reaction and Nucleic Acid hybridization.</p><p><b>RESULTS</b>Of 150 HBV DNA positive patients who lived in Shenzhen, 50 samples (33%) are type B, 36 samples (24%) are type C, 13 samples (9%) are type D, 3 samples is type F, 1 sample is type A, 48 samples (31%) are mixed type. The ALT value was significantly higher in genotype B than in genotype C. HBe positivity were higher in genotype B than genotype C. HBeAg positivity were higher in genotype C than in genotype B. There are not obvious relations between genotype and age or sex.</p><p><b>CONCLUSION</b>In the detected samples, the major genotype of HBV DNA is type B, several are type C, D. The type E haven't been found. There are some relations between all kinds of genotypes and the severity of hepatitis B.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
DNA, Viral
/
Hepatitis B virus
/
Polymerase Chain Reaction
/
Classification
/
Genetics
/
Genotype
/
Hepatitis B
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2004
Type:
Article
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