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The contrast study of Pre-S1 protein, HBV-DNA and HBeAg in diagnosing viral replication in patients with chronic hepatitis B / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 134-136, 2004.
Article in Chinese | WPRIM | ID: wpr-240465
ABSTRACT
<p><b>OBJECTIVE</b>To determine the role of Pre-S1 protein in diagnosing viral replication in patients with chronic hepatitis B.</p><p><b>METHODS</b>104 consecutive patients with chronic hepatitis B were included in the study, liver biopsy were performed in all patients. Serial serum samples were studied with the quantitative determination of HBV-DNA by a quantitative PCR assay, determination of Pre-S1 protein by ELISA.</p><p><b>RESULTS</b>The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg HBeAg anti-HBc (+) both were 96.5%. The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg anti-HBe anti-HBc (+) were 81.5%, 72.3%, respectively. The positive rates of HBV-DNA and Pre-S1 protein in patients with HBsAg anti-HBc (+) were 87.5%, 75.0%, respectively. It represented some patients with HBeAg (-) anti-HBe (+/-) still had viral replication. HBV-DNA>10(3) copy/ml as positive criteria for diagnosing viral replication, the positive rate of HBeAg, Pre-S1 were 31.5% (28/89), 80.9% (72/89) in patients with HBV-DNA>10(3) copy/ml, respectively. The concordance rates of HBeAg, Pre-S1 with HBV-DNA were 40.0% (42/104), 82.0% (85/104), respectively.</p><p><b>CONCLUSION</b>It showed that Pre-S1 was more sensitive than HBeAg in diagnosing viral replication in patients with chronic hepatitis B.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Protein Precursors / Virology / Virus Replication / Blood / DNA, Viral / Hepatitis B virus / Hepatitis B, Chronic / Hepatitis B e Antigens / Hepatitis B Surface Antigens Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Protein Precursors / Virology / Virus Replication / Blood / DNA, Viral / Hepatitis B virus / Hepatitis B, Chronic / Hepatitis B e Antigens / Hepatitis B Surface Antigens Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2004 Type: Article