Progress of new-generation genome editing mediated by engineered endonucleases / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 917-928, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-240576
ABSTRACT
Genome editing refers to the experimental methods to targeted modify specific loci in the genomic DNA sequence. In recent years, engineered endonucleases, including ZFN, TALEN and CRISPR/Cas, have been developed as a new-generation genome editing technique, and greatly improved the feasibility of gene function analyses, gene therapy, etc. Here, we briefly summarize the basic principle, developmental process and applications of this technology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Therapy
/
Genetic Engineering
/
Genome
/
Genomics
/
Endonucleases
/
Clustered Regularly Interspaced Short Palindromic Repeats
/
Genetics
/
Methods
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2015
Type:
Article
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