Intra-Arterial Cis-Diamminedichloroplatinum Infusion Treatment for Widespread Hepatocellular Carcinoma
Journal of the Korean Radiological Society
;
: 1025-1031, 1997.
Article
in Korean
| WPRIM
| ID: wpr-24070
ABSTRACT
PURPOSE:
To evaluate the therapeutic efficacy of intra-arterial infusion of Cis-Diamminedichloroplatinum (C-DDP) for the treatment of hepatocellular carcinomas with widespread involvement. MATERIALS ANDMETHODS:
We retrospectively analyzed 22 patients who between July 1994 and June 1996 had undergone intra-arterial c-DDP infusion therapy for the treatment of hepatocellular carcinomas with widespread involvement. The hepatomas involved both lobes in ten, portal venous obstructions in fourteen, arterio-portal shunts in nine, and arterio-venous shunts in two. Proper hepatic artery was selected for infusion of 100mg/BSA of C-DDP. The same procedure was repeated every 3 to 4 weeks, and the total number of infusions was 65. On the basis of WHO criteria, response was classified as complete remission, partial remission, stable, or progression of the disease. Six-month and one-year survival rates were estimated, and adverse reactions were evaluated.RESULTS:
Complete remission was noted in one patient (4.5%) and partial remission in three (13.6%), while 18 showed no response or progression after treatment. The six month survival rate was 59.1%, and the one-year survival rate was 32.1%. Adverse reactions included nausea/vomiting (59.8%), abdominal pain (9.2%), fever (8.0%), acute renal failure (2.3%) and hepatic encephalopathy (1.1%). These adverse reactions were, however, transient and reversible.CONCLUSION:
Although the response rate is not high, intra-arterial C-DDP infusion therapy can be used as an alternative treatment for hepatocellular carcinomas with widespread involvement; adverse reactions are tolerable.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Infusions, Intra-Arterial
/
Abdominal Pain
/
Hepatic Encephalopathy
/
Survival Rate
/
Retrospective Studies
/
Cisplatin
/
Carcinoma, Hepatocellular
/
Acute Kidney Injury
/
Fever
/
Hepatic Artery
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Radiological Society
Year:
1997
Type:
Article
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