Effect of shenfu injection on recovery of intestinal function, cellular immunity, serum interleukin-2 and tumor necrosis factor-alpha in children with intestinal obstruction after operation / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 744-746, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-240872
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Shenfu injection (SFI) on recovery of intestinal function, T-lymphocyte subsets (CD4, CD8 and CD4/CD8), interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in children with intestinal obstruction after surgical operation.</p><p><b>METHODS</b>Ninety-eight children suffering from intestinal obstruction after emergent surgical operation were divided into the SFI group (n = 50, treated with SFI after operation) and the control group (n = 48, treated with surgical operation alone). The intestinal function recovery rate (IFRR), T-lymphocyte subsets, serum levels of IL-2 and TNF-alpha in them were observed.</p><p><b>RESULTS</b>After being treated for 7 days, the IFRR in the SFI group was 84.0%, which was significantly higher than that in the control group (62.5%, P < 0.05). CD4, CD4/CD8 levels increased in the SFI group after treatment (P < 0.05), while in the control group, CD8 increased significantly after treatment (P < 0.05) and higher than that in SFI group (P < 0.01). IL-2 level was much higher in the SFI group after treatment than that in the control group (P < 0.05). TNF-alpha level significantly lowered in both groups (P < 0.01), and the level in the SFI group was lower than that in the control group (P < 0.05).</p><p><b>CONCLUSION</b>SFI could promote the recovery of intestinal function, improve and regulate the immune function of the children after operation for intestinal obstruction.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
General Surgery
/
Blood
/
Drugs, Chinese Herbal
/
Interleukin-2
/
Tumor Necrosis Factor-alpha
/
CD4-CD8 Ratio
/
Recovery of Function
/
Therapeutic Uses
/
Drug Therapy
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2003
Type:
Article
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