Effects of langchuangjing granule on apoptotic of CD4+ T and CD19+ B in spleen of BXSB mice with systemic lupus erythematosus / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 692-694, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-240885
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect on apoptotic of CD4+ T, CD19+ B in spleen of BXSB mice with systemic lupus erythematosus treated with Langchuangjing Granule and to probe into the mechanism of treatment.</p><p><b>METHODS</b>The apoptosis was examined by the flow cytometric analysis and immunofluorescence double-staining method.</p><p><b>RESULTS</b>Apoptosis of male BXSB mice speeds up. Langchuangjing Granule can restrain the excessive apoptosis of CD4+ T and CD19+ B cells in spleen.</p><p><b>CONCLUSION</b>Langchuangjing Granule treated systemic lupus erythematosus by restraining the excessive apoptotic of T, B lymphocytes, probably restraining the release of excessive amount of apoptotic DNA fragments, so decreasing abnormal proliferation of B cells and the produce of autoantibodies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Spleen
/
Drugs, Chinese Herbal
/
B-Lymphocytes
/
CD4-Positive T-Lymphocytes
/
Random Allocation
/
Apoptosis
/
Antigens, CD19
/
Allergy and Immunology
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2003
Type:
Article
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