Therapeutic efficacy of combined application of lamivudine and bushen recipe in treating chronic hepatitis B and its influence on YMDD motif / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 417-420, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-240943
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of combined application of Lamivudine and Bushen recipe (BSR) in treating patients with chronic hepatitis B (CHB) and its influence on tyrosine-methionine-aspartate-aspartate (YMDD) motif.</p><p><b>METHODS</b>Eighty-eight patients of CHB with positive HBV-DNA were divided into 3 groups, Group A treated with Lamivudine, Group B treated with Lamivudine plus BSR1 and Group C treated with Lamivudine plus BSR2, the serum HBV-DNA, hepatic biological parameters and YMDD motif mutation were observed.</p><p><b>RESULTS</b>The positive rate of HBV-DNA (6.45%) and YMDD motif mutation (3.23%) in Group C were lower than those in Group A respectively, after 52 weeks treatment.</p><p><b>CONCLUSION</b>Combined application of Lamivudine and BSR could enhance the therapeutic effect in treating CHB to certain extent, and could reduce the mutation of YMDD motif.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Drugs, Chinese Herbal
/
Hepatitis B virus
/
Conserved Sequence
/
Lamivudine
/
Hepatitis B, Chronic
/
Amino Acid Motifs
/
Therapeutic Uses
/
Drug Therapy
/
Drug Therapy, Combination
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2003
Type:
Article
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