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The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 319-324, 2005.
Article in English | WPRIM | ID: wpr-24110
ABSTRACT
Cervical cancer is one of the leading world causes of cancer morbidity and mortality in woman, with more than 98% related to a human papillomavirus (HPV) infection origin. Infection with specific subtypes of HPV has been strongly implicated in cervical carcinogenesis. The identification and functional verification of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis and the development of cervical cancer-specific markers. The advent of functional genomics and proteomics has provided hope of discovering novel biological markers for use in the screening, early diagnosis, prognostication and prediction of response to therapy. Herein, we review the studies where the profiles of host proteins associated with HPV E6 and E7 oncoproteins in cervical cancer were generated.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / Uterine Cervical Neoplasms / Mass Screening / Mortality / Oncogene Proteins / Genomics / Proteomics / Early Diagnosis / Carcinogenesis / Hope Type of study: Diagnostic study / Prognostic study / Screening study Limits: Female / Humans Language: English Journal: Cancer Research and Treatment Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / Uterine Cervical Neoplasms / Mass Screening / Mortality / Oncogene Proteins / Genomics / Proteomics / Early Diagnosis / Carcinogenesis / Hope Type of study: Diagnostic study / Prognostic study / Screening study Limits: Female / Humans Language: English Journal: Cancer Research and Treatment Year: 2005 Type: Article