Excretion of beta-elemene from rat respiratory tracts / 药学学报
Acta Pharmaceutica Sinica
;
(12): 54-56, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-241337
ABSTRACT
<p><b>AIM</b>To investigate the excretion of beta-elemene from the respiratory tracts in male Spraque-Dawley rats.</p><p><b>METHODS</b>After a single administration of beta-elemene to rats at the dosage of 75 mg x kg(-1) (i.v. or i.p.), the exhaled gases were collected and concentrated at various time points. The residues were analyzed by gas chromatography.</p><p><b>RESULTS</b>A minor amount of unchanged beta-elemene was excreted via rat respiratory tracts after iv and ip administration of a single dose. The cumulative excretion were 1.41% and 0.51% respectively.</p><p><b>CONCLUSION</b>The results demonstrated that unchanged beta-elemene excretes from rat respiratory tracts, but may not be the main elimination pathway in rats.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Respiratory System
/
Sesquiterpenes
/
Pharmacokinetics
/
Chemistry
/
Chromatography, Gas
/
Rats, Sprague-Dawley
/
Curcuma
/
Infusions, Parenteral
/
Injections, Intravenous
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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