M3-R/IK(M3)--a new target of antiarrhythmic agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 8-12, 2005.
Article
in English
| WPRIM
| ID: wpr-241347
ABSTRACT
<p><b>AIM</b>To investigate the relationship between M3-R/IK(M3) and arrhythmia in order to find a new target for antiarrhythmic agents.</p><p><b>METHODS</b>Using the acute ischemic model of rats and patch-clamp techniques, the effects of the M3 receptor on the occurrence of arrhythmias and its possible mechanisms were studied.</p><p><b>RESULTS</b>In acute ischemic model of rats, the M3 receptor antagonist 4-diphenylacetoxy-N-methylpiperidine-methiodide (4DAMP) increased the occurrence of arrhythmias, and the M3 receptor agonist choline suppressed the onset and the development of arrhythmias (P < 0. 01). No change was observed after treatment with other receptor antagonists (M1, M2, and M4). With patch-clamp techniques, it was found that choline induced K+ current could be inhibited by 4DAMP. Antagonists toward M1, M2, and M4 receptors all failed to alter the current.</p><p><b>CONCLUSION</b>Choline modulates the cellular electrical properties of the heart, probably by activating a K+ current via stimulation of the M3 receptor. M3-R/IK(M3) may act as a new target for antiarrhythmic agents.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Piperidines
/
Arrhythmias, Cardiac
/
Cell Separation
/
Choline
/
Rats, Wistar
/
Myocytes, Cardiac
/
Receptor, Muscarinic M3
/
Guinea Pigs
Limits:
Animals
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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