Pharmacokinetics and distribution of superoxide dismutase liposomes in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 173-177, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-241352
ABSTRACT
<p><b>AIM</b>To evaluate the effects of surfactants on the pharmacokinetics and distribution in rats after intravenous administration of SOD liposomes.</p><p><b>METHODS</b>The liposomes were prepared by reverse phase evaporation method. The activity of SOD was assayed by method of xanthine oxidase.</p><p><b>RESULTS</b>The T1/2 of SOD solution, common SOD liposome, SOD liposomes modified by DSPE-PEG2000 and Tween 80 were 0.25, 0.34, 0.66 and 0.41 h, respectively; AUC were 12.48, 24.66, 41.16 and 33.02 microg x h x mL(-1), respectively. Compared with the common liposome, the liposomes modified by DSPE-PEG and Tween 80 decreased the content of SOD in liver and spleen, but increased in brain.</p><p><b>CONCLUSION</b>The three kinds of liposomes could increase T1/2 and AUC in some extent, especially in PEG-L group. Tween-L could increase the SOD content in brain, and PEG-L could decrease the SOD content in the liver and spleen compared with the common liposome.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Polysorbates
/
Spleen
/
Superoxide Dismutase
/
Surface-Active Agents
/
Brain
/
Pharmacokinetics
/
Tissue Distribution
/
Random Allocation
/
Rats, Sprague-Dawley
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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