Metabolic pathways of dipfluzine in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 168-172, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-241353
ABSTRACT
<p><b>AIM</b>To investigate the metabolic pathways of dipfluzine in rats.</p><p><b>METHODS</b>After an oral dose of dipfluzine (80 mg x kg(-1)) to rats, urine was collected for 12 h. The metabolites of dipfluzine in urine were chromatographed and identified by LC/DAD/MS methods.</p><p><b>RESULTS</b>In the rat urine, there were 1-(4-fluorophenyl)-4-piperazinylbutanone and its glucuronide, 4-hydroxybenzophenone and its glucuronide, 4-fluoro-gamma-hydroxybenzenebutanoic acid and its glucuronide and sulfate, diphenylmethanol and its glucuronide, dipfluzine, and benzophenone.</p><p><b>CONCLUSION</b>In rats, dipfluzine was mainly metabolized in the pathways of N-desalkylation at 1- and 4-positions of piperazine ring. Some of metabolites were further conjugated with glucuronic acid and/or sulfuric acid.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urine
/
Benzophenones
/
Chromatography, Liquid
/
Cinnarizine
/
Rats, Wistar
/
Glucuronides
/
Gas Chromatography-Mass Spectrometry
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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