Chemical constituents from the seeds of Annona squamosa / 药学学报

ABSTRACT

<p><b>AIM</b>To study the antitumor active constituents of the seeds from Annona squamosa L. (Annonaceae).</p><p><b>METHODS</b>Various chromatographic techniques were used to isolate and purify the constituents. Their physico-chemical properties and spectral data were determined to elucidate the structures.</p><p><b>RESULTS</b>Eleven compounds were isolated and identified as annonaceous acetogenins squamocenin (1), annotemoyin-2 (2), reticulatain-2 (3), squamocin-I (4), squamocin-B (5), squamocin (6), motrilin (7), squamostatin-D (8), squamostatin-E (9), cherimolin-1 (10), cherimolin-2 (11) from the ethyl alcohol extract of A. squamosa L.</p><p><b>CONCLUSION</b>Squamocenin (1) is a new acetogenin. Annotemoyin-2 (2) and reticulatain-2 (3) were isolated from this plant for the first time.</p>