Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 136-140, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-241360
ABSTRACT
<p><b>AIM</b>To find new peroxisome proliferator-activated y agonists with high activity and low toxicity.</p><p><b>METHODS</b>Based on JTT-501 and JTT-20993, new isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds were designed and synthesized. Their insulin-sensitizing activities were evaluated.</p><p><b>RESULTS</b>Eight new compounds were obtained. The structures of synthesized compounds were characterized by NMR, MS and IR. Four compounds (1A-4A) showed insulin-sensitizing activities.</p><p><b>CONCLUSION</b>Compounds (1A and 3A) showed excellent insulin-sensitizing activities and should be worth further investigation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
3T3-L1 Cells
/
PPAR gamma
/
Glucose
/
Hypoglycemic Agents
/
Insulin
/
Isoxazoles
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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